Beilstein J. Org. Chem.2022,18, 524–532, doi:10.3762/bjoc.18.54
± 0.04 µM (100 ng/mL, 200 nM), respectively. Two compounds (3b and 10d) have also been tested for anti-SARS-CoV-2, antibacterial, and cytotoxic activity.
Keywords: antimalarial activity; anti-SARS-CoV-2activity; chloroquine; 2-nitroperchlorobutadiene; nucleophilic vinylic substitution; 1H-pyrazoles
PDF
Graphical Abstract
Figure 1:
The structures of chloroquine, hydroxychloroquine, and amodiaquine.